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а μ ӱ, Nature Genetics ǥ
2008.06.25
 

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1. Nat. Genet., Published online: 27 January 2008
"A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans"

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ֱ о߿ Ӱ ΰ ǰ ִ ý۽ (Systems biology) ٹ ̿Ͽ ټ ü Ʈũ Ž (Network-guided focused screen) Ͽ ξ żϰ Ȯϰ ִ ɼ Ͽٴ ߿ϴٰ ϰڽϴ.

[Ʈũ Ž ɿ]

ſ ߴ޵ ص 700 ̻ ü Գ ص Ǿ ׵ ִ ɵ Ǿ 𵨻ü鿡 ؼ ſ մϴ. Ư ܼ ܼ ̻鿡 Ͽ ξ ټ Ĺ鿡 ſ ̾մϴ. ֱ Ǵ ܼ ü (Caenorhabditis elegans) 20%, ܼ Ĺü ֱ (Arabidopsis thaliana) 15% ü ڵ Դϴ.

ϳ ü ȣ (, ܹ, ) (System) Ϸ ý۽ Դϴ. ٹ Ͽ װͰ ִ ٸ ڵ ̿ ϰ ǥ ڵ մϴ. ٹ ſ ִ ָް ֽϴ.

׷ ý۽ ߿ Ʈũ (Network) Դϴ. Ư Ʈũ (Gene network) ׸ װ (perturbation) ǥ ȭ , ؼϴµ ٽ Դϴ. ̷ Ʈũ ̿ ſ ̾ Ĺ ڿ ǥ Ʈũ ־ϴ.

- Ǽҵ

𵨸 ̵ ܼ ܼ ٻ ȿ (Yeast) ̹ ǥ Ǿϴ (Science 306:1555, 2004). ټ Ĺ ϱ ־ϴ. 2 Ѱ ȭ (optimization) Ͽ ü Ź Ʈũ Ȯ ϰ Ǿϴ.

Ʈũ ̹ ٸ 4 Nature, Science ǥǾ ־⿡ Ʈũ Ź ұϰ 8 ɻ źθ ߾ϴ. ɻ ߸ ؿ Ͽ ڿ Ͽ ɻ äõǰ Ǿϴ. ̷ 1 ģ ɻ ұϰ Nature Genetics ǥ(Cover) Ǿ־ ϳԲ ʹ ߽ϴ.

2. ߴ Ҽӱ Ǵ ҿ Ұ Ź帳ϴ.

ػ罺 п ġ Center for Systems and Synthetic Biology ߽ Ƿμ Ʈũ ̿ ý۽ , ׸ Mass spectrometry ̿ Proteomics, ׸ ׹ۿ ٸ large-scale, high-throughput, quantitative, integrative biology ַϰ ֽϴ. leader Dr. Edward Marcotte , ȭ, , , й о߿ Դϴ. 6 װ ̰ ƹ ȭ ٴ Դϴ. ׻ ϴ , ٸ ڵ ǰߵ̳ Ȳ ׻ Ϸ ϴ ڼ ٵ Դϴ.

3. о߷ Ϸ Ĺ Ǵ غ鿡 Ǵ ֽŴٸ?

̷ ڰ DZ ؼ θ Ͻñ ׻ ϰ ͽϴ. ٹ (Integrative collaborative approach) Ư п ־ break-through ϱ 䱸Ǵ Դϴ. ϱ ٴ ο ϰ װ͵ ܵ Ͽ ϴ ο ô ƹ ̻ ϴ. ο ޾Ƶ̴ , ׸ ٸ о ڵ ſ ߿ϴ Ͻϴ.

4. Ȱ õ ȹ ôٸ?

ݳ 3 б а մϴ. ý۽ п ɰ ذ Ե ϴ. ٶ ý о , ̳ ϰ ͽϴ.

5. ٸ Ͻð ̾߱....

The more learn, the less know. ǰϴ Դϴ.